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Correlation between psychological factors and the expression of galanin and 5.hydroxytryptamine in different subtypes of gastroesophageal reflux disease
Yuan Yuan1, Hui-Wen Xu2, Song Zhang3, En Takashi4, Kitayama Akio5, Jing-Yan Liang6
1 School of Nursing, Yangzhou University, Yangzhou, China; Division of Satoyama Nursing and Telecare, Nagano College of Nursing, Komagane, Japan
2 School of Nursing, Yangzhou University, Yangzhou, China; Division of Basic & Clinical Medicine, Nagano College of Nursing, Komagane, Japan
3 School of Nursing, Yangzhou University, Yangzhou, China
4 Division of Basic & Clinical Medicine, Nagano College of Nursing, Komagane, Japan
5 Division of Satoyama Nursing and Telecare, Nagano College of Nursing, Komagane, Japan
6 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China
Correspondence Address:
Prof. Jing-Yan Liang
Institute of Translational Medicine, Medical College, Yangzhou University, No. 136 Jiangyang Middle Road, Hanjiang District, Yangzhou 225000, Jiangsu Province
China
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/jin.jin_57_20
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Objective: The aim of this study is to analyze the differences in galanin (GAL) and 5-hydroxytryptamine (5-HT) levels in patients with different subtypes of gastroesophageal reflux disease (GERD) and its correlation with anxiety and depression in patients.
Methods: Using the reflux disease questionnaire, 238 patients with GERD were selected as the study group. According to the endoscopic performance, they were divided into the nonerosive reflux disease (NERD) group (114 patients) and the RE group (124 patients). Sixty healthy people were selected as the control group. All research subjects were tested using the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) to assess the severity of anxiety and depression. The levels of 5-HT and GAL were analyzed using enzyme-linked immunosorbent assay.
Results: Compared with the control group, 5-HT level in GERD patients without anxiety and depression was higher (t = 1.97, P < 0.05) and GAL level was lower (t = 1.97, P < 0.05). NERD patients demonstrated more server anxiety (F = 55.92, P < 0.05) and depression problems (F = 36.51, P < 0.05) compared to reflux esophagitis (RE) patients. The 5-HT level was lower (F = 54.53, P < 0.05) and the GAL level was higher (F = 8.00, P < 0.05) in NERD patients compared with the control group. Furthermore, 5-HT level was negatively correlated with SAS (r = −0.789, P < 0.05) and SDS (r = −0.787, P < 0.05) scores; GAL level was positively correlated with SAS (r = 0.688, P < 0.05) and SDS (r = 0.705, P < 0.05) scores; 5-HT and GAL level were negatively correlated (r= −0.744, P < 0.05).
Conclusions: 5-HT level is higher and GAL level was lower in GERD patients without anxiety and depression than healthy people; the symptoms of anxiety and depression of NERD patients are more severe compared to those of RE patients; the severity of anxiety and depression was negatively correlated with the level of 5-HT and positively with GAL level.
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